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CYP1A1 antibody

Anti-CYP1A1 antibody used in Western Blot (WB). GTX55582
Anti-CYP1A1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55582
Anti-CYP1A1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55582
Anti-CYP1A1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55582

Cat. No. GTX55582

Reference 2

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all CYP1A1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

58 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 200-460 of human CYP1A1 (NP_000490.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

cytochrome P450 family 1 subfamily A member 1 , AHH , AHRR , CP11 , CYP1 , CYPIA1 , P1-450 , P450-C , P450DX

Cellular Localization

Endoplasmic reticulum membrane,Mitochondrion inner membrane,Cytoplasm

Background

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

Database

Research Area

DATA IMAGES

Anti-CYP1A1 antibody used in Western Blot (WB). GTX55582

GTX55582 WB Image

WB analysis of various sample lysates using GTX55582 CYP1A1 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-CYP1A1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55582

GTX55582 IHC-P Image

IHC-P analysis of mouse spleen tissue using GTX55582 CYP1A1 antibody.
Dilution : 1:100

Anti-CYP1A1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55582

GTX55582 IHC-P Image

IHC-P analysis of rat lung tissue using GTX55582 CYP1A1 antibody.
Dilution : 1:100

Anti-CYP1A1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55582

GTX55582 IHC-P Image

IHC-P analysis of human placenta tissue using GTX55582 CYP1A1 antibody.
Dilution : 1:100

REFERENCE

Application Reference

Yanxin Wei et al. Phytomedicine 2023; : 154980 Maintenance of airway epithelial barrier integrity via the inhibition of AHR/EGFR activation ameliorates chronic obstructive pulmonary disease using effective-component combination
Reactivity : Rat
H Shang et al. Cell Biosci 2023; 13 (1) : 127 Gut microbiota-derived tryptophan metabolites alleviate liver injury via AhR/Nrf2 activation in pyrrolizidine alkaloids-induced sinusoidal obstruction syndrome
Application : WB
Submit a Reference

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399