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CYP2B6 antibody

Anti-CYP2B6 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX56284
Anti-CYP2B6 antibody used in Western Blot (WB). GTX56284
Anti-CYP2B6 antibody used in IHC (Paraffin sections) (IHC-P). GTX56284

Cat No. GTX56284

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF, IHC-P

Reactivity

Human
Package
100 μl ($339)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:1000
ICC/IF 1:100 - 1:500
IHC-P 1:100 - 1:200
Not tested in other applications.

Calculated MW

56 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.42% Potassium phosphate, 0.87% Sodium chloride pH 7.3, 30% glycerol, 0.01% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of CYP2B6. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

cytochrome P450 family 2 subfamily B member 6 , CPB6 , CYP2B , CYP2B7 , CYP2B7P , CYPIIB6 , EFVM , IIB1 , P450

Background

This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-CYP2B6 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX56284

GTX56284 ICC/IF Image

ICC/IF analysis of formalin-fixed HepG2 cells using GTX56284 CYP2B6 antibody.
Red : Primary antibody
Blue : DAPI
Permeabilization : 0.1% Triton X-100 in TBS for 5-10 minutes

Anti-CYP2B6 antibody used in Western Blot (WB). GTX56284

GTX56284 WB Image

WB analysis of HepG2 (A) whole cell lysates using GTX56284 CYP2B6 antibody.

Anti-CYP2B6 antibody used in IHC (Paraffin sections) (IHC-P). GTX56284

GTX56284 IHC-P Image

IHC-P analysis of formalin fixed human breast cancer tissue section using GTX56284 CYP2B6 antibody.
Antigen retrieval : Heat mediated antigen retrieval with sodium citrate buffer (pH 6.0)

REFERENCE

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REVIEW

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SDS
Glycerol.pdf
Sodium Azide.pdf