*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
Human, Rat, Bovine(>80% identity)
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Recombinant protein encompassing a sequence within the center region of human CYP46A1. The exact sequence is proprietary.
Purified by antigen-affinity chromatography.
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
CP46 antibody, CYP46 antibody, CYP46A1 antibody, cytochrome P450 46A1 antibody, cholesterol 24-hydroxylase antibody, CH24H antibody, "cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase) antibody", "cytochrome P450, family 46, subfamily A, polypeptide 1 antibody"
Endoplasmic reticulum membrane , Microsome membrane
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq]
GTX105183 WB Image
Sample (50 ug of whole cell lysate)
A: Mouse brain
7.5% SDS PAGE
GTX105183 diluted at 1:1000