GeneTex
United States (US)

CYP46A1 antibody

Overexpression
GTX30682_242_ICC-IF_18121410_872.jpg
GTX30682_1483_WB_18121410_972.jpg
GTX30682_1484_WB_18121410_388.jpg
GTX30682_1640_WB_18121410_757.jpg

Cat No. GTX30682

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF, IHC-P
Reactivity Human, Rabbit
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:1000
ICC/IF 1:500
IHC-P 1:200
Not tested in other applications.

Calculated MW

57 kDa. ( Note )

Specificity/Sensitivity

This product does not react with Mouse.
PROPERTIES

Form

Liquid

Buffer

Serum

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to residues between 200-250 of human CYP46A1. [UniProt# Q9Y6A2]

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Cytochrome P450 Family 46 Subfamily A Member 1,Cp46,Cyp46,Cyp46A1

Cellular Localization

Endoplasmic reticulum membrane,Microsome membrane

Background

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq]

Database

Research Area

DATA IMAGES
GTX30682_242_ICC-IF_18121410_872.jpg

GTX30682 ICC/IF Image

ICC/IF analysis of SH-SY5Y cells using GTX30682 CYP46A1 antibody.
Green : primary antibody
Red : Tubulin
Blue : DAPI

GTX30682_1483_WB_18121410_972.jpg

GTX30682 WB Image

Overexpression

WB analysis of HEK293 mock (Lane 1) or overexpressing CYP46A1 (Lane 2) cell lysate using GTX30682 CYP46A1 antibody.

GTX30682_1484_WB_18121410_388.jpg

GTX30682 WB Image

WB analysis of human brain tissue lysate using GTX30682 CYP46A1 antibody.

GTX30682_1640_WB_18121410_757.jpg

GTX30682 WB Image

WB analysis of transfected 293 cells using GTX30682 CYP46A1 antibody.

Package List Price ($)
$ 319