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Calbindin antibody [CB-955]

Cat No. GTX30888

Host Mouse
Clonality Monoclonal
Clone Name CB-955
Isotype IgG1
Application IHC-P
Reactivity Human, Mouse, Rat, Rabbit, Goat, Sheep, Bovine, Cat, Dog, Guinea pig, Pig
Package
500 μl ($319)
APPLICATION

Application Note

For IHC-P: Use at a dilution of 1:150-1:300 in ABC method. An incubation period of 30 minutes at room temperature is suggested. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 or enzymatic digestion prior to immunostaining. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

30 kDa. ( Note )

Positive Control

Kidney

Specificity/Sensitivity

Antibody reacts specifically with calbindin-D-28K in brain and kidney tissues from human, cow, goat, pig, rabbit, dog, cat, rat, mouse, sheep, and guinea pig sources. It binds weakly to chicken calbindin-D-28K.
PROPERTIES

Form

Liquid

Buffer

Ascites containing 0.09% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Bovine

Immunogen

Purified bovine kidney calbindin-D-28K

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Calbindin 1,Calb1

Cellular Localization

Cytoplasmic/Cell membrane

Background

Calbindin D28k is a member of a large family of intracellular calcium-binding proteins, containing EF-hand calcium binding motifs, and is related to calmodulin and troponin-C. The biological roles of Calbindin D28k include calcium regulation and calcium-dependent signalling in neurons and during development. Decreases in Calbindin D28k abundance, or loss of Calbindin D28k immunoreactivity, is found in models of neurological disorders such as epilepsy, and in neurodegenerative diseases. This Calbindin antibody is often used as a marker for cerebellum Purkinje cells.

Database

Research Area

REFERENCE
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REVIEW
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Package List Price ($)
$ 319