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Caldesmon antibody [hHCD]

Anti-Caldesmon antibody [hHCD] used in IHC (Paraffin sections) (IHC-P). GTX03317

Cat. No. GTX03317

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 hHCD

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($399)
See all Caldesmon products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:50-1:100

Note :

IHC-P
Pretreatment : EDTA Buffer pH 8.0 for 30 min at RT
Not tested in other applications.

Calculated MW

93 kDa. ( Note )

Positive Control

Endometrial cancer

Product Note

This antibody is specific to high molecular weight (120-150 kDa) h-caldesmon. The h-caldesmon variant is predominantly expressed in smooth muscle, whereas l-caldesmon (71-80 kD) is found in non-muscle tissue and cells.

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

BALB/C mice were injected with human uterus smooth muscle extract.

Purification

Purified IgG

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

caldesmon 1 , CDM , H-CAD , HCAD , L-CAD , LCAD , NAG22

Cellular Localization

Cytoplasm, cytoskeleton

Background

This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Caldesmon antibody [hHCD] used in IHC (Paraffin sections) (IHC-P). GTX03317

GTX03317 IHC-P Image

IHC-P analysis of human endometrial carcinoma tissue section using GTX03317 Caldesmon antibody [hHCD].

REFERENCE

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REVIEW

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Package List Price ($)
$ 399