GeneTex
United States (US)

Calnexin antibody [CANX/1541]

GTX34446_20170712_IHC-P_2_18121410_258.jpg
GTX34446_20170712_IHC-P_1_18121410_133.jpg
GTX34446_20170712_IHC-P_18121410_487.jpg

Cat No. GTX34446

Host Mouse
Clonality Monoclonal
Clone Name CANX/1541
Isotype IgG2b
Application IHC-P
Reactivity Human
APPLICATION

Application Note

IHC-P:1-2ug/ml for 30 minutes at RT.

Calculated MW

68 kDa. ( Note )

Specificity/Sensitivity

It recognizes a protein of 90kDa, which is identified as Calnexin. Secretory and transmembrane proteins are synthesized on polysomes and translocate into the endoplasmic reticulum (ER) where they are often modified by the formation of disulfide bonds, amino-linked glycosylation and folding. To help proteins fold properly, the ER contains a pool of molecular chaperones including calnexin. It is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant N-terminal fragment of human Calnexin protein (exact sequence is proprietary)

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Calnexin,Cnx,Ip90,P90,Canx

Background

This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
GTX34446_20170712_IHC-P_2_18121410_258.jpg

GTX34446 IHC-P Image

Formalin-fixed, paraffin-embedded human Small Intestinal Carcinoma stained with Calnexin Monoclonal Antibody (CANX/1541).

GTX34446_20170712_IHC-P_1_18121410_133.jpg

GTX34446 IHC-P Image

Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with Calnexin Monoclonal Antibody (CANX/1541).

GTX34446_20170712_IHC-P_18121410_487.jpg

GTX34446 IHC-P Image

Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with Calnexin Monoclonal Antibody (CANX/1541).

Package List Price ($)
$ 329