APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500 - 1:2000 |
| 1:50 - 1:100 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS, 50% Glycerol
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 69-268 of human CAPNS1 (NP_001740.1).
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
calpain small subunit 1 , CALPAIN4 , CANP , CANPS , CAPN4 , CDPS , CSS1
Cellular Localization
Cytoplasm,Cell membrane
Background
This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Database
Research Area
DATA IMAGES
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GTX33058 IHC-P Image
IHC-P analysis of human liver cancer tissue using GTX33058 Calpain S1 antibody.
Dilution : 1:100
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GTX33058 WB Image
WB analysis of various sample lysates using GTX33058 Calpain S1 antibody.
Dilution : 1:1000
Loading : 25μg per lane
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GTX33058 IHC-P Image
IHC-P analysis of human colon tissue using GTX33058 Calpain S1 antibody.
Dilution : 1:100
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GTX33058 IHC-P Image
IHC-P analysis of human esophageal cancer tissue using GTX33058 Calpain S1 antibody.
Dilution : 1:100
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REFERENCE
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REVIEW
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