PRODUCT
Summary
A serine protease inhibitor inhibiting plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancreatic fibrosis. Reduces weight gain and improves metabolism in obese rodent models. In clinical use (in Japan) for pancreatitis. Inhibits influenza virus replication in human tracheal epithelial cells. Reduces infection of Calu-3 lung cells by SARS-CoV-2 (responsible for COVID-19) via inhibition of the serine protease TMPRSS2 required for viral spike protein priming.
CAS No.: 59721-29-8
Physical Properties: Off-white powder
Chemical formula: C₂₀ H ₂₂ N₄O₅•CH₃SO₃H
Molecular weight: 494.5
PROPERTIES
Form
Lyophilized powder
Buffer
Reconstitute with DMSO (50mg/ml) or water (50mg/ml).
Preservative
No preservative
Storage
Store desiccated as supplied at -20ºC for up to 2 years. Store solutions at -20ºC for up to 1 month.
Purity
>98% (HPLC); NMR (Conforms)
Conjugation
Unconjugated
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
4-(2-(2-(dimethylamino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate, methanesulfonic acid salt , FOY-305 , Foipan
REFERENCE
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REVIEW
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