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Carbonic Anhydrase IX antibody [66.4.C2]

Cat. No. GTX01814

Reference 5

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 66.4.C2

Isotype

 IgG2a

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($399)
See all Carbonic Anhydrase IX products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:100‐1:200

Note :

IHC-P
Pretreatment of deparaffinized tissue with heat‐induced epitope retrieval or enzymatic retrieval is recommended.
Not tested in other applications.

Calculated MW

50 kDa. ( Note )

Positive Control

Normal kidney or renal cell carcinoma

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant diluted in Tris-HCl buffer, 0.2% BSA

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Antigen Species

Human

Immunogen

Native from human renal cortical tissue homogenate

Purification

unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CA9,CAIX,MN,carbonic anhydrase 9,Carbonic Anhydrase IX

Cellular Localization

Nucleus,Nucleolus,Cell membrane,Cell projection,Microvillus membrane

Background

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jun 2014]

Database

Research Area

REFERENCE

Clone Reference

2019; Renal Cell Carcinoma Antigen Expression in Primary Cutaneous Endocrine Mucinous Carcinomas: A Case Series of 14 Patients and Review of the Literature
Reactivity : Human
2018; Clear Cell Renal Cell Carcinoma Metastatic to the Gynecologic Tract: A Clinicopathologic Analysis of 17 Cases
Reactivity : Human
2017; Molecular and cytogenomic profiling of hepatic adenocarcinoma expressing inhibinA, a mimicker of neuroendocrine tumors: proposal to reclassify as "cholangioblastic variant of intrahepatic cholangiocarcinoma"
Reactivity : Human
2016; Primary Renal Rhabdomyosarcoma in an Adolescent With Tumor Thrombosis in the Inferior Vena Cava and Right Atrium: A Case Report and Review of the Literature
Application : IHC-P
Reactivity : Human
2015; Acquired cystic disease-associated renal cell carcinoma with a focal sarcomatoid component: Report of a case showing more pronounced polysomy of chromosomes 3 and 16 in the sarcomatoid component
Application : IHC-P
Reactivity : Human
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REVIEW

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Package List Price ($)
$ 399