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Carbonic Anhydrase IX antibody [TH22]

Anti-Carbonic Anhydrase IX antibody [TH22] used in IHC (Paraffin sections) (IHC-P). GTX01918

Cat. No. GTX01918

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 TH22

Isotype

 IgG2a

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($479)
See all Carbonic Anhydrase IX products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:100

Note :

IHC-P
The recommended fixative is 10% neutral-buffered formalin for paraffin-embedded tissue sections.
Not tested in other applications.

Calculated MW

50 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

Prokaryotic recombinant protein corresponding to 118 amino acids of the human Carbonic Anhydrase IX molecule.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

carbonic anhydrase 9 , CAIX , MN

Cellular Localization

Nucleus , Cell membrane , Nucleolus

Background

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jun 2014]

Database

Research Area

DATA IMAGES

Anti-Carbonic Anhydrase IX antibody [TH22] used in IHC (Paraffin sections) (IHC-P). GTX01918

GTX01918 IHC-P Image

IHC-P analysis of human stomach tissue using GTX01918 Carbonic Anhydrase IX antibody [TH22]. Note intense membrane and cytoplasmic staining of the deep glands.

REFERENCE

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REVIEW

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Package List Price ($)
$ 479