GeneTex
United States (US)

Cardiac Troponin C antibody [12G3]

Cat No. GTX10245

Host Mouse
Clonality Monoclonal
Clone Name 12G3
Isotype IgG2b
Application WB, ELISA, Apuri
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
ELISA Assay dependent
Apuri Assay dependent
Not tested in other applications.

Calculated MW

18.4 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS pH 7.4, 0.09 % sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4º C.

Concentration

Batch dependent

Antigen Species

Human

Immunogen

Human cardiac troponin C.

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Troponin C1, Slow Skeletal And Cardiac Type,Cmd1Z,Cmh13,Tn-C,Tnc,Tnnc,Tnnc1

Background

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]

Database

Package List Price ($)
$ 289