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Cardiac Troponin I antibody [16A11]

Cat No. GTX38804

Host Mouse
Clonality Monoclonal
Clone Name 16A11
Isotype IgG1
Application WB, ELISA, Apuri
Reactivity Human
Package
500 μg ($329)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
ELISA Assay dependent
Apuri Assay dependent
Not tested in other applications.

Calculated MW

24 kDa. ( Note )

Specificity/Sensitivity

Reacts equally with free cardiac troponin I (cTnI) and cTnI forming complexes with other troponincomponents. Not affected by heparin, phosphorylation, oxidation and troponin complex formation.Recognizes an epitope located between amino acid residues 86 and 90 of cTnI. No cross-reactivity withskeletal muscle troponin I. Reactive with cTnI from human, bovine, porcine, goat, canine, rabbit, and feline.Not reactive with cTnI from rat, mouse or fish.
PROPERTIES

Form

Liquid

Buffer

PBS pH 7.4, 0.09% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

6 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Native Troponin Complex

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Troponin I3, Cardiac Type,Cmd1Ff,Cmd2A,Cmh7,Rcm1,Tnnc1,Ctni,Tnni3

Background

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE
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REVIEW
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Package List Price ($)
$ 329