*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
Reacts equally with free cardiac troponin I (cTnI) and cTnI forming complexes with other troponincomponents. Not affected by heparin, phosphorylation and oxidation. Recognizes an epitope locatedbetween amino acid residues 169 and 178 of cTnI. Cross reactivity with skeletal Troponin I is < 10% .
PBS pH 7.4, 0.09% sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Mixture of cTnI and cTnI in native complex.
Protein A purified
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
CTNI Antibody , CMD2A Antibody , CMH7 Antibody , TNNI3 Antibody , RCM1 Antibody , TNNC1 Antibody , CMD1FF Antibody
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]