*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
Reacts with free cardiac troponin I (cTnI). Reacts weakly with cTnI forming complexes with other troponin components.Not affected by phosphorylation. Recognizes an epitope located between amino acid residues 148 and 158 of cTnI. Nocross-reactivity with skeletal muscle troponin I.
PBS pH 7.4, 0.1% sodium azide
Free human cTnI and native human cTn complex
Protein A purified
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TNNI3 Antibody , RCM1 Antibody , TNNC1 Antibody , CMD1FF Antibody , CTNI Antibody , CMD2A Antibody , CMH7 Antibody
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]