*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
CKI-alpha (Ab-321) Antibody detects endogenous levels of total Casein Kinase 1 alpha protein.
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
The antiserum was produced against synthesized peptide derived from human Casein Kinase 1 alpha.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
kinase CK1-alpha, EC126.96.36.199, KC1A, kinase CK1alpha, Casein kinase I, CKI-alpha, CKIalpha, CK1alpha, CKI alpha, CK1-alpha, alpha isoform, CSNK1A1, EC 188.8.131.52, CK1 alpha, kinase CK1 alpha
Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis.
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis.