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Caspase-1/3/8/9/10/12 Inhibitor Plus, Q-VD-OPh

Caspase-1/3/8/9/10/12 Inhibitor Plus, Q-VD-OPh. GTX47939
Caspase-1/3/8/9/10/12 Inhibitor Plus, Q-VD-OPh. GTX47939

Cat No. GTX47939

Application

Neutralizing/Inhibition
Package
1 mg ($249)
PRODUCT

Summary

Next generation cell permeable peptide inhibitor for Caspase family

APPLICATION

Application Note

We recommend a working concentration of 1-10 uM for in vitro studies.

Calculated MW

513.49 Da kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

In DMSO (10 mM solution)

Storage

Store at -20ºC. Protect from light and moisture.

Concentration

10 (Please refer to the vial label for the specific concentration.)

Purity

>95% by HPLC

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Caspase-1 inhibitor Caspase-3 inhibitor Caspase-8 inhibitor C , Quinolyl-Val-Asp-Oph , Caspase1 inhibitor Caspase3 inhibitor Caspase8 inhibitor C , Caspase Inhibitor , QuinolylValAspOph , QValAspOph , Quinolyl Val Asp Oph

Background

A synthetic peptide that is potent, cell permeable, nontoxic and irreversibly inhibits caspase activity to blocks apoptosis.
The new generation of caspase inhibitor is more stable in aqueous environment and exhibits several folds higher activity than the corresponding FMK caspase inhibitors. Q-VD-OPh is the inhibitor of choice for both in vitro and in vivo studies. IC 50 = 20-40 nM.

DATA IMAGES

Caspase-1/3/8/9/10/12 Inhibitor Plus, Q-VD-OPh. GTX47939

GTX47939 Image

Caspase-1/3/8/9/10/12 Inhibitor Plus, Q-VD-OPh. GTX47939

GTX47939 Neutralizing/Inhibition Image

Inhibition of Caspase-3 activity by next generation caspase inhibitor, Q-VD-OPh: Different concentrations of inhibitor Q-VD-OPh were tested to check the inhibition of Caspase-3 activity. Active Caspase-3 was incubated with the inhibitor Q-VD-OPh for 7 min prior to addition of synthetic peptide substrate DEVD-AFC (AFC,7-amino-4-trifluoromethyl coumarin). Fluorescence was measured at Ex/Em = 400/505 nm.

REFERENCE

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REVIEW

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Package List Price ($)
$ 249