GeneTex
United States (US)

Caspase 1 peptide

Cat No. GTX27988

Application Blocking
Reactivity Human
Species Human
APPLICATION

Application Note

Blocking peptide for Rabbit polyclonal to Caspase 1 (ICE) (GTX27978)
PROPERTIES

Form

Liquid

Buffer

PBS with 100ug BSA 0.1% sodium azide

Storage

Keep as concentrated solution, aliquot and store at 4ºC.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Caspase 1,Ice,Il1Bc,P45,Casp1

Cellular Localization

Cytoplasmic

Background

Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. Caspase 1 is similar to the cell death gene CED3 of C. elegans and regulates multiple proinflammatory cytokines, including Interleukin 1b and interferon-gamma-inducing factor. Caspase 1 plays a role in down stream of Caspase 8 which is involved in Fas-mediated apoptosis.

Research Area