GeneTex
United States (US)

Caspase 12 antibody

GTX12333_IHC-P_1_18121410_799.jpg
GTX12333_IHC-P_18121410_862.jpg

Cat No. GTX12333

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

39 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

5% BSA, 0.9% NaCl, 0.2% Na2HPO4, 0.05% Thimerosal, 0.05% NaN3.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.)

Concentration

0.50mg/ml

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminal of human CASP12

Purification

Immunogen affinity purified.

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

CASP-12 Antibody, CASP12P1 Antibody, caspase 12 (gene/pseudogene) Antibody

Background

Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]
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Database

Research Area

DATA IMAGES
GTX12333_IHC-P_1_18121410_799.jpg

GTX12333 IHC-P Image

IHC(P): Human Lung Cancer Tissue

GTX12333_IHC-P_18121410_862.jpg

GTX12333 IHC-P Image

IHC(P): Human Mammary Cancer Tissue