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Caspase 14 antibody

Anti-Caspase 14 antibody used in IHC (Paraffin sections) (IHC-P). GTX85087
Anti-Caspase 14 antibody used in Western Blot (WB). GTX85087

Cat No. GTX85087

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P, ELISA

Reactivity

Human, Mouse, Rat
Package
100 μg ($369)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

28 kDa. ( Note )

Positive Control

Jurkat Cell Lysate(GTX27899) , Human Liver Tissue Slide , Human Liver Tissue Lysate

PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Caspase-14 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human caspase-14.The immunogen is located within the last 50 amino acids of Caspase-14.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

caspase 14 , ARCI12

Cellular Localization

Cytoplasm,Nucleus

Background

Caspases are a family of cysteine proteases that can be divided into apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1b and IL-18. Caspase-14 is highly expressed in embryonic but not adult tissues. It is processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in the keratinocyte terminal differentiation, which is important for the formation of the skin barrier.

Database

Research Area

DATA IMAGES

Anti-Caspase 14 antibody used in IHC (Paraffin sections) (IHC-P). GTX85087

GTX85087 IHC-P Image

IHC-P analysis of human liver tissue using GTX85087 Caspase 14 antibody.
Working concentration : 2.5 μg/ml

Anti-Caspase 14 antibody used in Western Blot (WB). GTX85087

GTX85087 WB Image

WB analysis of Jurkat cell lysate in the (A) absence or (B) presence of blocking peptide using GTX85087 Caspase 14 antibody.
Working concentration : 1 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 369