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Caspase 3 antibody [C33]

Orthogonal
Anti-Caspase 3 antibody [C33] used in Western Blot (WB). GTX59551
Anti-Caspase 3 antibody [C33] used in Western Blot (WB). GTX59551
Anti-Caspase 3 antibody [C33] used in Western Blot (WB). GTX59551
Anti-Caspase 3 antibody [C33] used in Western Blot (WB). GTX59551

Cat. No. GTX59551

Reference 3

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 C33

Isotype

 IgG1

Application

 WB

Reactivity

 Human, Mouse, Rat
Package
50 μg ($399)
See all Caspase 3 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.5-4 μg/ml
Not tested in other applications.

Calculated MW

31.61 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol, 0.5mg/ml BSA

Preservative

0.01% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human Caspase-3

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_10728836

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CASP3 , CPP32 , CPP32B , SCA1 , caspase 3 , Caspase 3

Cellular Localization

Cytoplasm

Background

The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]

Database

Research Area

DATA IMAGES

Anti-Caspase 3 antibody [C33] used in Western Blot (WB). GTX59551

GTX59551 WB Image

WB analysis of HeLa cells treated with camptothecin (2μM) lysate using GTX59551 Caspase 3 antibody [C33].

Anti-Caspase 3 antibody [C33] used in Western Blot (WB). GTX59551

GTX59551 WB Image

Orthogonal

The data was published in the 2018 in J Exp Clin Cancer Res. PMID: 30482226

Anti-Caspase 3 antibody [C33] used in Western Blot (WB). GTX59551

GTX59551 WB Image

Orthogonal

The data was published in the 2018 in J Exp Clin Cancer Res. PMID: 30482226

Anti-Caspase 3 antibody [C33] used in Western Blot (WB). GTX59551

GTX59551 WB Image

Orthogonal

The data was published in the 2018 in J Exp Clin Cancer Res. PMID: 30482226

REFERENCE

Application Reference

Salaroglio IC et al. J Exp Clin Cancer Res 2018; 37 (1) : 286 increasing intratumor c/ebp-β lip and nitric oxide levels overcome resistance to * in triple negative breast cancer.
Application : WB
Reactivity : Human
Salaroglio IC et al. Mol Cancer Ther 2018; (Epub) carbonic anhydrase xii inhibitors overcome p-glycoprotein-mediated resistance to * in glioblastoma.
Application : WB
Reactivity : Human
Pinzon-Daza ML et al. J Cereb Blood Flow Metab 2014; 34 (8) : 1258-69 The cross-talk between canonical and non-canonical Wnt-dependent pathways regulates P-glycoprotein expression in human blood-brain barrier cells.
Application : WB
Reactivity : Human
Submit a Reference

REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 399