10mM Phosphate-buffered saline containing 0.2% BSA and 0.1% sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
1 mg/ml (Please refer to the vial label for the specific concentration.)
Recombinant full length human caspase 3 protein.
Protein A affinity purified
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Caspase 3 , Cpp32 , Cpp32B , Sca-1 , Casp3
Caspase 3 is ubiquitously expressed and like other caspases is synthesized as an inactive (32 kD) proenzyme. Recent studies have implicated that Caspase 3 is associated with the induction of apoptosis. Activation of Caspase 3 occurs in response to variety of apoptotic inducers including Fas mediated apoptosis. Upon activation, Caspase 3 is cleaved at Asp28-Ser29 and Asp175-Ser176, thereby generating two subunits of 17 kD and 12 kD, respectively.