Caspase 3 p17 subunit antibody

Cat. No. GTX49360

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC-P
Reactivity	Human
Package	100 μl ($399)

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Datasheet
Document

View product citations for antibody GTX49360 on CiteAb

APPLICATION

Application Note

WB: 1:500 - 1:1000, IHC-P: 1:50 - 1:200

Calculated MW

32 kDa. ( Note )

Product Note

Actived-Caspase-3 p17 pAb detects endogenous levels of Actived-Caspase-3 p17 protein.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide conjugated to KLH derived from within residues 150 - 200 of Human active Caspase 3.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

caspase 3 , CPP32 , CPP32B , SCA-1

Cellular Localization

Cytoplasm

Background

The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]

Database

Gene ID: 836 CASP3
UniProt: P42574 CASP3

Research Area

DATA IMAGES

GTX49360 IHC-P Image

Immunohistochemistry (IHC) analyzes of Actived-Caspase-3 p17 pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

GTX49360 WB Image

Western blot (WB) analysis of Actived-Caspase-3 p17 pAb at 1:500 dilution. Lane1:Hela whole cell lysate(40ug). Lane2:Hela treated with H2O2 (100nmol/ml, 25min, phostop) whole cell lysate (40ug). Lane3:Hela treated with H2O2 (100nmol/ml, 25min, λ-ppase)

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SDS
PBS.pdf
Sodium Azide.pdf

Package

List Price ($)

100 μl

$ 399

Qty