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Caspase 8 antibody

Cat No. GTX73092

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P, IP

Reactivity

Human, Mouse, Rat
Package
500 μl ($319)

APPLICATION

Application Note

For IHC-P: Use at a dilution of 1:1,000. For IP: Use at a dilution of 1:2,000. For WB: Use at a diltuion of 1:500. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

55 kDa. ( Note )

Positive Control

Jurkat Cells, Stomach

Specificity/Sensitivity

It is recommended for detection of the p18 subunit and precursor of caspase-8 of mouse, rat and human origin.

PROPERTIES

Form

Liquid

Buffer

10mM Phosphate-buffered saline containing 0.2% BSA and 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The epitope corresponding to amino acids 217-350 mapping within the caspase-8 p18 subunit of human origin.

Purification

Protein A affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Caspase 8 , Alps2B , Cap4 , Casp-8 , Flice , Mach , Mch5 , Casp8

Cellular Localization

Cytoplasmic

Background

Caspase 8 binds to the death effector domain (DED) of FADD through an analogous DED domain present in tandem in the proform of the Caspase 8 protein. Recruitment of Caspase 8 to the Fas receptor results in oligomerization of the Caspase 8 protein, which in turn drives its autoactivation through ""self-cleavage"". Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby commiting the cell to undergo apoptosis. Reacts with Jurkat cells and Tonsil.

Database

Research Area

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 319