APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500~1:1000 |
Not tested in other applications.
Calculated MW
Product Note
Cathepsin C (cleaved Arg394) antibody detects endogenous levels of fragment of activated cathepsin C resulting from cleavage adjacent to Arg394.
PROPERTIES
Form
Liquid
Buffer
PBS, 150mM NaCl, 50% Glycerol
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
The antiserum was produced against synthesized peptide derived from human Cathepsin C (345-394).
Purification
Purified by antigen-affinity chromatography
From serum
Conjugation
Unconjugated
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
CPPI , CTSC , DPP1 , DPPI , HMS , JP , JPD , PALS , PDON1 , PLS , cathepsin C , Cathepsin C
Cellular Localization
Lysosome
Background
This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. [provided by RefSeq, Nov 2015]
Database
Research Area
DATA IMAGES
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GTX86919 WB Image
WB analysis of Jurkat cells treated with etoposide 25uM (1h) lysate using GTX86919 Cathepsin C (cleaved Arg394) antibody. The lane on the right is blocked with the synthesized peptide.
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REFERENCE
There are currently no references for Cathepsin C (cleaved Arg394) antibody (GTX86919). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Cathepsin C (cleaved Arg394) antibody (GTX86919). Be the first to share your experience with this product.
