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Cav alpha 2/delta 2 antibody

Anti-Cav alpha 2/delta 2 antibody used in Western Blot (WB). GTX53487
Anti-Cav alpha 2/delta 2 antibody used in IHC (Paraffin sections) (IHC-P). GTX53487
Anti-Cav alpha 2/delta 2 antibody used in Western Blot (WB). GTX53487
Anti-Cav alpha 2/delta 2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX53487

Cat. No. GTX53487

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human, Mouse
Package
400 μl ($399)
See all Cav alpha 2/delta 2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:2000
ICC/IF 1:10-1:50
IHC-P 1:10-1:50
Not tested in other applications.

Calculated MW

130 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide between 643-671 amino acids from the Central region of human CACNA2D2.

Purification

Protein A purified, followed by peptide affinity purification.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

calcium voltage-gated channel auxiliary subunit alpha2delta 2 , CACNA2D

Cellular Localization

Membrane

Background

Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

Database

Research Area

DATA IMAGES

Anti-Cav alpha 2/delta 2 antibody used in Western Blot (WB). GTX53487

GTX53487 WB Image

WB analysis of mouse kidney lysate using GTX53487 Cav alpha 2/delta 2 antibody.
Loading : 20 μg per lane
Dilution : 1:2000

Anti-Cav alpha 2/delta 2 antibody used in IHC (Paraffin sections) (IHC-P). GTX53487

GTX53487 IHC-P Image

IHC-P analysis of human cerebellum tissue using GTX53487 Cav alpha 2/delta 2 antibody.

Anti-Cav alpha 2/delta 2 antibody used in Western Blot (WB). GTX53487

GTX53487 WB Image

WB analysis of human testis lysate using GTX53487 Cav alpha 2/delta 2 antibody.
Loading : 20 μg per lane
Dilution : 1:2000

Anti-Cav alpha 2/delta 2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX53487

GTX53487 ICC/IF Image

ICC/IF analysis of U251 cells using GTX53487 Cav alpha 2/delta 2 antibody.
Green : CACNA2D2
Red : Actin filament
Fixation : 4% paraformaldehyde (PFA) (20 min)
Permeabilization : Triton X-100 (0.1%, 10 min)
Dilution : 1:25

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399