GeneTex
United States (US)

Cav1.2 antibody, C-term

GTX88630_2206_WB_18121411_911.jpg

Cat No. GTX88630

Host Goat
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1-3μg/ml
Not tested in other applications.

Calculated MW

249 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX88630-PEP).

Specificity/Sensitivity

This antibody is expected to recognise all reported human isoforms.
PROPERTIES

Form

Liquid

Buffer

Tris saline pH7.3, 0.02% sodium azide, 0.5% BSA.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.50 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide with sequence C-RARGRPSEEELQD, from the C Terminus of the protein sequence according to NP_000710.5; NP_955630.2; NP_001161097.1; NP_001123299.1; NP_001123301.1; NP_001161096.1; NP_001123302.1; NP_001123303.1 and more.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Calcium Voltage-Gated Channel Subunit Alpha1 C,Cach2,Cacn2,Cacnl1A1,Cchl1A1,Cav1.2,Lqt8,Ts,Cacna1C

Cellular Localization

The interaction between RRAD and CACNB2 regulates its trafficking to the cell membrane.

Background

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]

Database

Research Area

DATA IMAGES
GTX88630_2206_WB_18121411_911.jpg

GTX88630 WB Image

WB analysis of human heart lysate using GTX88630 Cav1.2 antibody, C-term.
Dilution : 1µg/ml
Loading : 35µg protein in RIPA buffer

Package List Price ($)
$ 329