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Cav1.2 antibody

Anti-Cav1.2 antibody used in Western Blot (WB). GTX16608

Cat No. GTX16608

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF

Reactivity

Human, Mouse, Rat
Package
50 μl ($569)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
ICC/IF Assay dependent
Not tested in other applications.

Calculated MW

249 kDa. ( Note )

Product Note

The antibody recognizes mouse CaV1.2, splice variants P22002-4 and P22002-5 of rat CaV1.2 and splice variant P15381-4 of rabbit CaV1.2.

PROPERTIES

Form

Liquid

Buffer

PBS pH7.4, 1% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.8 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide VNENTRMYIPEENHQ(C), corresponding to amino acid residues 2-15 (Intracellular, N-terminus) of human CaV1.2 (exon 1B) (Accession  : Q13936).

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

calcium voltage-gated channel subunit alpha1 C , CACH2 , CACN2 , CACNL1A1 , CCHL1A1 , CaV1.2 , LQT8 , TS

Cellular Localization

Cell membrane,Cell projection, dendrite

Background

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]

Database

  • Gene ID: 775 CACNA1C
  • UniProt: Q13936 CACNA1C

Research Area

DATA IMAGES

Anti-Cav1.2 antibody used in Western Blot (WB). GTX16608

GTX16608 WB Image

WB analysis of rat heart membrane lysate using GTX16608 Cav1.2 antibody preincubated with or without immunogen peptide.
Dilution : 1:200

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 569