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Cav1.2 antibody

Anti-Cav1.2 antibody used in Western Blot (WB). GTX16608

Cat. No. GTX16608

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF

Reactivity

 Human, Mouse, Rat
Package
50 μl ($639)
See all Cav1.2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
Not tested in other applications.

Calculated MW

249 kDa. ( Note )

Product Note

The antibody recognizes mouse CaV1.2, splice variants P22002-4 and P22002-5 of rat CaV1.2 and splice variant P15381-4 of rabbit CaV1.2.

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.8 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide VNENTRMYIPEENHQ(C), corresponding to amino acid residues 2-15 (Intracellular, N-terminus) of human CaV1.2 (exon 1B) (Accession  : Q13936).

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

calcium voltage-gated channel subunit alpha1 C , CACH2 , CACN2 , CACNL1A1 , CCHL1A1 , CaV1.2 , LQT8 , TS

Cellular Localization

Cell membrane,Cell projection, dendrite

Background

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]

Database

  • Gene ID: 775 CACNA1C
  • UniProt: Q13936 CACNA1C

Research Area

DATA IMAGES

Anti-Cav1.2 antibody used in Western Blot (WB). GTX16608

GTX16608 WB Image

WB analysis of rat heart membrane lysate using GTX16608 Cav1.2 antibody preincubated with or without immunogen peptide.
Dilution : 1:200

REFERENCE

Application Reference

Osuru HP et al. Front Cardiovasc Med 2022; 9 : 711421 Molecular and Cellular Response of the Myocardium (H9C2 Cells) Towards Hypoxia and HIF-1α Inhibition.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 639