GeneTex
United States (US)

Cav1.2 antibody

GTX16608_WB_18121410_140.jpg

Cat No. GTX16608

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF
Reactivity Human, Mouse, Rat
APPLICATION

Calculated MW

249 kDa. ( Note )

Specificity/Sensitivity

The antibody recognizes mouse CaV1.2, splice variants P22002-4 and P22002-5 of rat CaV1.2 and splice variant P15381-4 of rabbit CaV1.2.
PROPERTIES

Form

Liquid

Buffer

Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Peptide VNENTRMYIPEENHQ(C), corresponding to amino acid residues 2-15 of human Cav1.2 (exon 1B) (Accession Q13936). Intracellular, N-terminus.

Purification

Affinity purified on immobilized antigen.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Calcium Voltage-Gated Channel Subunit Alpha1 C,Cach2,Cacn2,Cacnl1A1,Cchl1A1,Cav1.2,Lqt8,Ts,Cacna1C

Background

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]

Database

Research Area

DATA IMAGES
GTX16608_WB_18121410_140.jpg

GTX16608 WB Image

Anti-Human_CaV1.2 - Western blot analysis of rat heart membranes: 1. Anti-Human-Cav1.2 antibody, (1:200). 2. Anti-Human-Cav1.2 antibody, preincubated with the control peptide antigen.

Package List Price ($)
$ 329