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Claudin 18.2 antibody [ARC5062-02]

Anti-Claudin 18.2 antibody [ARC5062-02] used in IHC (Paraffin sections) (IHC-P). GTX04575
Anti-Claudin 18.2 antibody [ARC5062-02] used in IHC (Paraffin sections) (IHC-P). GTX04575

Cat. No. GTX04575

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 ARC5062-02

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human
Package
100 μl ($399)
See all Claudin 18 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:500-1:1000
Not tested in other applications.

Calculated MW

28 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS pH 7.3, 0.05% BSA, 50% glycerol

Preservative

0.05% proclin300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLDN18.2 (P56856-2).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

claudin 18 , SFTA5 , SFTPJ

Cellular Localization

Cell junction, tight junction , Cell membrane

Background

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]

Database

Research Area

DATA IMAGES

Anti-Claudin 18.2 antibody [ARC5062-02] used in IHC (Paraffin sections) (IHC-P). GTX04575

GTX04575 IHC-P Image

IHC-P analysis of human stomach tissue using GTX04575 Claudin 18.2 antibody [ARC5062-02].
Antigen retrieval : 10 mM Tris/EDTA buffer, pH 9.0
Dilution : 1:50

Anti-Claudin 18.2 antibody [ARC5062-02] used in IHC (Paraffin sections) (IHC-P). GTX04575

GTX04575 IHC-P Image

IHC-P analysis of human stomach tissue using GTX04575 Claudin 18.2 antibody [ARC5062-02].
Antigen retrieval : 10 mM Tris/EDTA buffer, pH 9.0
Dilution : 1:50

REFERENCE

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REVIEW

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Package List Price ($)
$ 399