APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500-1:1000 |
| 1:50-1:200 |
| 1:50-1:200 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.05% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic peptide, corresponding to amino acids 171-220 of Human Claudin-7.
Purification
Purified by antigen-affinity chromatography
From serum
Purity
> 95% (by SDS-PAGE)
Conjugation
Unconjugated
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
claudin 7 , CEPTRL2 , CLDN-7 , CPETRL2 , Hs.84359 , claudin-1
Cellular Localization
Cell membrane
Background
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]
Database
Research Area
DATA IMAGES
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GTX66616 WB Image
WB analysis of various samples using GTX66616 Claudin 7 antibody.
Lane1 : HCC827 whole cell lysate(40ug)
Lane2 : The Lung tissue lysate of Mouse(40ug)
Lane3 : The Lung tissue lysate of Rat(40ug)
Lane4 : A549 whole cell lysate(40ug)
Lane5 : L02 whole cell lysate(40ug)
Dilution : 1:500
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GTX66616 IHC-P Image
IHC-P analysis of human breast carcinoma tissue using GTX66616 Claudin 7 antibody.
Dilution : 1:100
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GTX66616 IP Image
IP analysis of Hela cell lysate using GTX66616 Claudin 7 antibody (Lane 2 and 3) and nonspecific IgG control antibody (Lane 4 and 5) compared to the input control (Lane 1).
Upward arrow : supernatant
Downward arrow : Immunoprecipitants
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REFERENCE
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REVIEW
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