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United States (US)

Collagen II antibody

Cat. No. GTX44077

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 IHC-P, IHC-Fr, ELISA

Reactivity

 Mouse
Package
100 μl ($399)
See all Collagen II products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:1,000
IHC-Fr 1:80
ELISA 1:200
Not tested in other applications.

Calculated MW

142 kDa. ( Note )

Product Note

Cross-reactivity (RIA% ):Mouse Collagen Type II 100% Mouse Collagen Type I, III, IV <0.1% Mouse Fibronectin <0.1%

PROPERTIES

Form

Liquid

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Extracted and purified from mouse fetal cartilage.

Purification

Purified by Column Chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

collagen, type II, alpha 1 , Col2 , Col2a , Col2a-1 , Del1 , Dmm , Lpk , M100413 , Rgsc413 , Rgsc856

Background

This gene encodes the alpha-1 subunit of the fibril-forming type II collagen, the major component of cartilage and the vitreous humor of the eye. The encoded preproprotein forms homotrimeric, triple helical procollagen that undergoes proteolytic processing during fibirl formation. Mice harboring certain mutations in this gene exhibit severe chondrodysplasia characterized by short limbs and trunch, craniofacial deformities and cleft palate. A complete lack of the encoded protein in mice results in postnatal lethality. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Dec 2015]

Database

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 399