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United States (US)

Collagen II antibody

Cat. No. GTX44078

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 ICC/IF, IHC-P, IHC-Fr, ELISA, RIA

Reactivity

 Human
Package
100 μl ($399)
See all Collagen II products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF Assay dependent
IHC-P 1:1,000
IHC-Fr 1:80
ELISA 1:200
RIA Assay dependent
Not tested in other applications.

Calculated MW

142 kDa. ( Note )

Product Note

Cross-Reactivity: (% 1:200 RIA Dilution)Human Collagen Type II 100% Human Collagen Type I, IV <1.0% Human Collagen Types III, V, IX, XI <0.1% Human Fibronectin <0.1%

PROPERTIES

Form

Liquid

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Collagen Type II extracted and purified from human cartilage.

Purification

Purified by Ion Exchange Chromatography (DEAE-Trisacryl)

Conjugation

Unconjugated

RRID

AB_11165209

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

collagen type II alpha 1 chain , ANFH , AOM , COL11A3 , SEDC , STL1

Background

This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

Application Reference

Resca E et al. Placenta 2013; 34 (7) : 526-35 Enrichment in c-Kit+ enhances mesodermal and neural differentiation of human chorionic placental cells.
Application : ICC/IF
Reactivity : Human
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Package List Price ($)
$ 399