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Collagen III antibody [FH-7A]

Anti-Collagen III antibody [FH-7A] used in IHC (Frozen sections) (IHC-Fr). GTX26310
Anti-Collagen III antibody [FH-7A] used in IHC (Paraffin sections) (IHC-P). GTX26310

Cat. No. GTX26310

Reference 10

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 FH-7A

Isotype

 IgG1

Application

 WB, IHC-P, IHC-Fr, Dot, ELISA

Reactivity

 Human, Rat, Rabbit
Package
100 μl ($439)
See all Collagen III products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-P Assay dependent
IHC-Fr 1:4,000
Dot Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

139 kDa. ( Note )

Positive Control

human skin

Product Note

Type III collagen, [a1(III)]3 ,is an approx. 300 kDa molecule, found predominantly in skin, blood vessels, liver, placenta, tongue, and thymus. Collagen type III forms cofibrils with type I and/or V collagens in a number of tissues of mesenchymal origin, such as skin, tendon, ligaments, and bone. This collagen type is involved, directly or indirectly in several genetic diseases, including Ehlers-Danlos type IV disease.

PROPERTIES

Form

Liquid

Buffer

Ascites

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

human collagen type III

Purification

Unpurified

Conjugation

Unconjugated

RRID

AB_385206

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

collagen type III alpha 1 chain , EDS4A , EDSVASC

Background

Collagen III is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I Collagen. Mutations in the gene are associated with Ehlers Danlos syndrome type IV, and with aortic and arterial aneurysms. Although alternate transcripts have been detected for this gene, they are the result of mutations; these mutations alter splicing, often leading to the exclusion of multiple exons.

Database

Research Area

DATA IMAGES

Anti-Collagen III antibody [FH-7A] used in IHC (Frozen sections) (IHC-Fr). GTX26310

GTX26310 IHC-Fr Image

IHC-Fr analysis of rat skin tissue using GTX26310 Collagen III antibody [FH-7A] at 1:8,000.

Anti-Collagen III antibody [FH-7A] used in IHC (Paraffin sections) (IHC-P). GTX26310

GTX26310 IHC-P Image

IHC-P analysis of rat skin using GTX26310 Collagen III antibody [FH-7A] at 1:4000.

REFERENCE

Application Reference

Wang X et al. Heliyon 2023; 9 (4) : e14800 Fabrication of bFGF/polydopamine-loaded PEEK implants for improving soft tissue integration by upregulating Wnt/β-catenin signaling.
Application : WB
Reactivity : Rabbit
Xiao W et al. Sci Adv 2022; 8 (28) : eabn1958 Recombinant DTβ4-inspired porous 3D vascular graft enhanced antithrombogenicity and recruited circulating CD93+/CD34+ cells for endothelialization.
Quintero Sierra LA et al. Tissue Eng Regen Med 2022; Tissue-Material Integration and Biostimulation Study of Collagen Acellular Matrices.
Application : IHC-P
Reactivity : Human
Alexandr Kurkov et al. PLoS One 2021; 16 (1) : e0245159 Amianthoid transformation of costal cartilage matrix in children with pectus excavatum and pectus carinatum.
Application : IHC-P
Reactivity : Human
Julia Fern?ndez-P?rez et al. PLoS One 2021; 16 (6) : e0245406 The effect of prior long-term recellularization with keratocytes of decellularized porcine corneas implanted in a rabbit anterior lamellar keratoplasty model.
Application : IHC-P
Reactivity : Rabbit
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REVIEW

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Application Reference
Wang X et al. Heliyon 2023; 9 (4):e14800 Fabrication of bFGF/polydopamine-loaded PEEK implants for improving soft tissue integration by upregulating Wnt/β-catenin signaling.
Application : WB
Reactivity : Rabbit
Xiao W et al. Sci Adv 2022; 8 (28):eabn1958 Recombinant DTβ4-inspired porous 3D vascular graft enhanced antithrombogenicity and recruited circulating CD93+/CD34+ cells for endothelialization.
Quintero Sierra LA et al. Tissue Eng Regen Med 2022; Tissue-Material Integration and Biostimulation Study of Collagen Acellular Matrices.
Application : IHC-P
Reactivity : Human
Alexandr Kurkov et al. PLoS One 2021; 16 (1):e0245159 Amianthoid transformation of costal cartilage matrix in children with pectus excavatum and pectus carinatum.
Application : IHC-P
Reactivity : Human
Julia Fern?ndez-P?rez et al. PLoS One 2021; 16 (6):e0245406 The effect of prior long-term recellularization with keratocytes of decellularized porcine corneas implanted in a rabbit anterior lamellar keratoplasty model.
Application : IHC-P
Reactivity : Rabbit
De Francesco F et al. J Int Med Res 2020; 48 (8):3.00061E+14 Artificial dermal substitutes for tissue regeneration: comparison of the clinical outcomes and histological findings of two templates.
Application : IHC-P
Reactivity : Human
Wu PT et al. J Biol Chem 2019; 294 (52):20177-20184 Inhibition of CD44 induces apoptosis, inflammation, and matrix metalloproteinase expression in tendinopathy.
Lewis AT et al. J Biophotonics 2017; Developing Raman Spectroscopy as a Diagnostic Tool for Label-free Antigen Detection.
Application : IHC-P
Reactivity : Human
Hamakawa H et al. Am J Respir Cell Mol Biol 2011; 45 (3):517-24 Structure-function relations in an elastase-induced mouse model of emphysema.
Clone Reference
Wang P et al. Stem Cell Res Ther. 2017; 8 (1):114 Basic fibroblast growth factor reduces scar by inhibiting the differentiation of epidermal stem cells to myofibroblasts via the Notch1/Jagged1 pathway.
Application : IHC-P
Reactivity : Rabbit
SDS
Sodium Azide.pdf
Package List Price ($)
$ 439