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Collagen V antibody [MC5-HA]

Anti-Collagen V antibody [MC5-HA] used in Immunohistochemistry (IHC). GTX19812

Cat No. GTX19812

Host Mouse
Clonality Monoclonal
Clone Name MC5-HA
Isotype IgM
Application WB, IHC-Fr, ELISA, IHC-F, IHC, RIA
Reactivity Human
Package
500 μl ($319)
APPLICATION

Application Note

ELISA: 1/1000. IHC-Fr: 1/20 if FITC-labeled secondary antibodies are used. Otherwise use at an assay dependent dilution. RIA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: ~180 kDa. Is unsuitable for IHC-P. Optimal dilutions/concentrations should be determined by the end user.

Specificity/Sensitivity

GTX19812 reacts with native human as well as heat denatured human collagen type V in RIA, ELISA and immunoblot/WB assays. Does not react with other collagen types I, II, III, and IV. Human plasma proteins do not interfere with binding to collagen.
PROPERTIES

Form

Liquid

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Full length native protein (purified) (Human).

Purification

Purified IgM
PEG6000 precipitation and Sepharose 6B gel filtration.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Cellular Localization

Cytoplasmic

Background

Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Collagen V is composed of several subunits as follows: trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Type V Collagen is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue specific chain combinations. Mutations in this gene are associated with Ehlers Danlos syndrome, types I and II.

Research Area

DATA IMAGES
Anti-Collagen V antibody [MC5-HA] used in Immunohistochemistry (IHC). GTX19812

GTX19812 IHC Image


REFERENCE
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Package List Price ($)
$ 319