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Connexin 43 antibody

Orthogonal
Anti-Connexin 43 antibody used in IHC (Paraffin sections) (IHC-P). GTX50571
Anti-Connexin 43 antibody used in Western Blot (WB). GTX50571

Cat. No. GTX50571

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Rabbit
Package
100 μl ($399)
See all Connexin 43 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:1000
IHC-P 1:50-1:100
Not tested in other applications.

Calculated MW

43 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS (without Mg²⁺ and Ca²⁺) pH7.4, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide sequence around aa. 366~370 (R-A-S-S-R) derived from human Connexin 43.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

gap junction protein alpha 1 , AVSD3 , CMDR , CX43 , EKVP , EKVP3 , GJAL , HLHS1 , HSS , ODDD , PPKCA

Cellular Localization

Cell membrane,Endoplasmic reticulum

Background

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014]

Database

Research Area

DATA IMAGES

Anti-Connexin 43 antibody used in IHC (Paraffin sections) (IHC-P). GTX50571

GTX50571 IHC-P Image

Orthogonal

IHC-P analysis of human breast carcinoma tissue using GTX50571 Connexin 43 antibody.
Left : Primary antibody
Right : Primary antibody pre-incubated with the antigen specific peptide

Anti-Connexin 43 antibody used in Western Blot (WB). GTX50571

GTX50571 WB Image

Orthogonal

WB analysis of extracts from HT-29 and HepG2 cells using GTX50571 Connexin 43 antibody.

REFERENCE

Application Reference

Hui-Ling Lee et al. Front Physiol 2021; 12 : 726389 Beneficial Electrophysiological Effects of Rotigaptide Are Unable to Suppress Therapeutic Hypothermia-Provoked Ventricular Fibrillation in Failing Rabbit Hearts With Acute Ischemia-Reperfusion Injury.
Application : WB
Reactivity : Rabbit
Submit a Reference

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399