GeneTex
United States (US)

Cyclin A antibody

Cyclin-A-antibody_WB_GTX27956-1_18121409_119.jpg

Cat No. GTX27956

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IP, IHC
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

WB: starting dilution at 1:200

Positive Control

K562

Specificity/Sensitivity

Reacts with cyclin A2
PROPERTIES

Form

Liquid

Buffer

PBS with 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Synthetic peptide: HSKYHSVSLLNPPETLSV (Mouse) (C terminal).

Purification

IgG fraction

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Ccna, CCNA2, Cyca, P20248, 12428, AA408589, 890, CCN1, Cyclin A, Ccn-1, 123835, Ccn 1

Cellular Localization

Nuclear

Background

During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by activating Cdks (1,2). Cyclin A regulates at least two cdks, Cdc2 p34 and Cdk2, and is believed to be necessary for progression through S phase and is active during the G2-M transition (1&3,4). Cyclin B1 also associates with Cdc2 p34 and this complex is requisite for the G2-M progression. The Cyclin B1/Cdc2 p34 complex is known as MPF, M-phase kinase, maturation-promoting factor, or M-phase specific histone kinase, is widely accepted as the trigger of mitosis in all organisms (5-9).
DATA IMAGES
Cyclin-A-antibody_WB_GTX27956-1_18121409_119.jpg

GTX27956 WB Image

Western Blot expression of Cyclin A in HeLA (B) whole cell lysates

REFERENCE
Package List Price ($)
$ 319