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Cyclin D1 antibody [SP4]

Anti-Cyclin D1 antibody [SP4] used in IHC (Paraffin sections) (IHC-P). GTX04738

Cat. No. GTX04738

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 SP4

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($659)
See all Cyclin D1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:25-1:100

Note :

IHC-P
Recommendations for antigen retrieval : EDTA Buffer pH 8.0 at room temperature for 30 mins.
Not tested in other applications.

PROPERTIES

Form

Liquid

Buffer

batch dependent

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide from C-terminus of human cyclin D1.

Purification

Unpurified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

BCL1,CCND1,D11S287E,PRAD1,U21B31,cyclin D1,Cyclin D1

Cellular Localization

Nucleus,Cytoplasm,Membrane

Background

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Cyclin D1 antibody [SP4] used in IHC (Paraffin sections) (IHC-P). GTX04738

GTX04738 IHC-P Image

IHC-P analysis of human breast tissue using GTX04738 Cyclin D1 antibody [SP4].
Antigen retrieval : EDTA Buffer pH 8.0_x000D_ _x000D_

REFERENCE

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REVIEW

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Package List Price ($)
$ 659