APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:25-1:100 |
|
Note :
IHC-P
Recommendations for antigen retrieval : EDTA buffer pH 8.0
|
Not tested in other applications.
PROPERTIES
Form
Liquid
Buffer
batch dependent
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
A synthetic peptide from C-terminus of human cyclin D1.
Purification
Unpurified
From tissue culture supernatant
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
BCL1,CCND1,D11S287E,PRAD1,U21B31,cyclin D1,Cyclin D1
Cellular Localization
Nucleus,Cytoplasm,Membrane
Background
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
![Anti-Cyclin D1 antibody [SP4] used in IHC (Paraffin sections) (IHC-P). GTX04743](/templates/default/js/lightbox/images/loading.gif "Anti-Cyclin D1 antibody [SP4] used in IHC (Paraffin sections) (IHC-P). GTX04743")
|
GTX04743 IHC-P Image
IHC-P analysis of human breast tissue using GTX04743 Cyclin D1 antibody [SP4].
Antigen retrieval : EDTA Buffer pH 8.0
|
REFERENCE
There are currently no references for Cyclin D1 antibody [SP4] (GTX04743). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Cyclin D1 antibody [SP4] (GTX04743). Be the first to share your experience with this product.
![Anti-Cyclin D1 antibody [SP4] used in IHC (Paraffin sections) (IHC-P). GTX04743](/upload/website/prouct_img/small/GTX04743/GTX04743_20240325_IHC-P_24032423_828.webp "Anti-Cyclin D1 antibody [SP4] used in IHC (Paraffin sections) (IHC-P). GTX04743")
![Anti-Cyclin D1 antibody [SP4] used in IHC (Paraffin sections) (IHC-P). GTX04743](/upload/website/prouct_img/normal/GTX04743/GTX04743_20240325_IHC-P_24032423_828.webp "Anti-Cyclin D1 antibody [SP4] used in IHC (Paraffin sections) (IHC-P). GTX04743")