GeneTex
United States (US)

Cyclin D1 antibody

Cat No. GTX27958

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-Fr, IP
Reactivity Human, Mouse, Rat
APPLICATION

Calculated MW

34 kDa. ( Note )

Positive Control

Jurkat

Specificity/Sensitivity

Reacts with cyclin D1 and weakly cross reactive with cyclin D2
PROPERTIES

Form

Liquid

Buffer

PBS with 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide (Human) (C terminal).

Purification

IgG fraction

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Cyclin D1,Bcl1,D11S287E,Prad1,U21B31,Ccnd1

Cellular Localization

Nuclear

Background

During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by activating Cdks (1,2). Early in the G1 phase of the cell cycle cyclin D1 induction is followed by cyclin E induction (3,4). This sequential progression is marked early on in G1by the activation of Cdk4 and in mid to late G1 by the activation of Cdk2 and the hyperphosphorylation of pRB (3,5). The final transition into S phase is thought to be dependent on the increased expression and association of cyclin E and Cdk2 (5,6).

Database

Research Area

REFERENCE
Package List Price ($)
$ 319