GeneTex
United States (US)

Cyclin E antibody [168]

Cat No. GTX16122

Host Mouse
Clonality Monoclonal
Clone Name 168
Isotype IgG2a
Application WB, IP
Reactivity Human, Monkey
APPLICATION

Application Note

IP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Detects a band of approximately 50 kDa. Optimal dilutions/concentrations should be determined by the end user.
PROPERTIES

Form

Liquid

Buffer

Preservative: 0.08% Sodium Azide; Constituents: PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant full length protein (Human).

Purification


This antibody is provided as a 0.2 μm sterile filtered solution.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

CCNE1, CCNE, P24864, 898, 123837, Cyclin E

Cellular Localization

Nuclear

Background

Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are expressed only in tumors but not in the normal tissues, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
Package List Price ($)
$ 329