Form
Liquid
Buffer
Tissue culture supernatant with 15 mM sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Antigen Species
Human
Immunogen
human cystatin A
Purification
Unpurified
Conjugation
Unconjugated
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Synonyms
cystatin A , AREI , PSS4 , STF1 , STFA
Cellular Localization
Cytoplasm
Background
Cystatins are endogenous inhibitors of lysosomal proteases that form a superfamily that is classified into three families (families 1,2 and 3) according to the homology of the amino acid sequences. Cystatin A (also termed acid cysteine proteinase inhibitor, ACPI, stefin A, and epidermal SH- proteinase inhibitor) belongs to family 1 of the cystatin superfamily of proteins. These proteins are natural inhibitors of cysteine proteinases like cathepsin B, H, L, and S. Cystatin A, a 98 amino acid protein (11-13 kDa), is detected in normal squamous epithelium, follicular dendritic cells in lymphoid tissues, thymic epithelial cells (in Hassall_x0019_s corpuscles and in medulla), liver cells, granulocytes and basal epithelial cells in the prostate. Cystatin A is thought to be a tumor suppressor, since an inverse correlation seems to exist between the level of cystatin A and tumor progression, in several malignancies. Also, Cystatin A has been implicated in aging of tissues, Alzheimer disease, viral infections and inflammatory processes. Antibodies that react specifically with cystatin A are useful tools for studying structure-function relationships and cellular or subcellular localization of the molecule.
Database
