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Cystatin A antibody [WR-23/2/3/3]

Cat No. GTX10442

Host Mouse
Clonality Monoclonal
Clone Name WR-23/2/3/3
Isotype IgG1
Application WB, IHC-P
Reactivity Human
Package
50 μl ($289)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
IHC-P 1:4,000
Not tested in other applications.

Calculated MW

11 kDa. ( Note )

Positive Control

human thymus
PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant with 15 mM sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

human cystatin A

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

cystatin A , AREI , PSS4 , STF1 , STFA

Cellular Localization

Cytoplasm

Background

Cystatins are endogenous inhibitors of lysosomal proteases that form a superfamily that is classified into three families (families 1,2 and 3) according to the homology of the amino acid sequences. Cystatin A (also termed acid cysteine proteinase inhibitor, ACPI, stefin A, and epidermal SH- proteinase inhibitor) belongs to family 1 of the cystatin superfamily of proteins. These proteins are natural inhibitors of cysteine proteinases like cathepsin B, H, L, and S. Cystatin A, a 98 amino acid protein (11-13 kDa), is detected in normal squamous epithelium, follicular dendritic cells in lymphoid tissues, thymic epithelial cells (in Hassall_x0019_s corpuscles and in medulla), liver cells, granulocytes and basal epithelial cells in the prostate. Cystatin A is thought to be a tumor suppressor, since an inverse correlation seems to exist between the level of cystatin A and tumor progression, in several malignancies. Also, Cystatin A has been implicated in aging of tissues, Alzheimer disease, viral infections and inflammatory processes. Antibodies that react specifically with cystatin A are useful tools for studying structure-function relationships and cellular or subcellular localization of the molecule.

Database

REFERENCE
There are currently no references for Cystatin A antibody [WR-23/2/3/3] (GTX10442). Be the first to share your publications with this product.
REVIEW
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Package List Price ($)
$ 289