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Cytochrome P450 2D6 antibody [GT1357]

Anti-Cytochrome P450 2D6 antibody [GT1357] used in IHC (Paraffin sections) (IHC-P). GTX03703
Anti-Cytochrome P450 2D6 antibody [GT1357] used in IHC (Paraffin sections) (IHC-P). GTX03703
Anti-Cytochrome P450 2D6 antibody [GT1357] used in Western Blot (WB). GTX03703

Cat. No. GTX03703

Host

Rabbit

Clonality

Monoclonal

Clone Name

GT1357

Isotype

IgG

Application

WB, IHC-P

Reactivity

Human, Mouse, Rat
Package
100 μl ($419)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:2000
IHC-P 1:50-1:200
Not tested in other applications.

Calculated MW

56 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 0.05% BSA, 50% glycerol

Preservative

0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthesized peptide derived from human CYP2D6.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

cytochrome P450 family 2 subfamily D member 6 , CPD6 , CYP2D , CYP2D7AP , CYP2D7BP , CYP2D7P2 , CYP2D8P2 , CYP2DL1 , CYPIID6 , P450-DB1 , P450C2D , P450DB1

Background

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Database

Research Area

DATA IMAGES

Anti-Cytochrome P450 2D6 antibody [GT1357] used in IHC (Paraffin sections) (IHC-P). GTX03703

GTX03703 IHC-P Image

IHC-P analysis of mouse liver tissue using GTX03703 Cytochrome P450 2D6 antibody [GT1357].
Dilution : 1:100
Blue : DAPI

Anti-Cytochrome P450 2D6 antibody [GT1357] used in IHC (Paraffin sections) (IHC-P). GTX03703

GTX03703 IHC-P Image

IHC-P analysis of rat liver tissue using GTX03703 Cytochrome P450 2D6 antibody [GT1357].
Dilution : 1:100
Blue : DAPI

Anti-Cytochrome P450 2D6 antibody [GT1357] used in Western Blot (WB). GTX03703

GTX03703 WB Image

WB analysis of various sample lysates using GTX03703 Cytochrome P450 2D6 antibody [GT1357].
Dilution : 1:1000
Loading : 25 μg per lane

REFERENCE

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REVIEW

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Package List Price ($)
$ 419