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Cytokeratin 6a antibody [rKRT6A/2100]

Anti-Cytokeratin 6a antibody [rKRT6A/2100] used in IHC (Paraffin sections) (IHC-P). GTX02661

Cat. No. GTX02661

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 rKRT6A/2100

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
100 μg ($529)
See all Cytokeratin 6a products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1-2 μg/ml

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris buffer with 1mM EDTA (pH 9.0) for 45 min at 95ºC followed by cooling at RT for 20 minutes.
Not tested in other applications.

Calculated MW

60 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant full-length human Cytokeratin 6A (KRT6A) protein

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

keratin 6A , CK-6C , CK-6E , CK6A , CK6C , CK6D , K6A , K6C , K6D , KRT6C , KRT6D , PC3

Background

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014]

Database

Research Area

DATA IMAGES

Anti-Cytokeratin 6a antibody [rKRT6A/2100] used in IHC (Paraffin sections) (IHC-P). GTX02661

GTX02661 IHC-P Image

IHC-P analysis of human pancreas tissue section using GTX02661 Cytokeratin 6a antibody [rKRT6A/2100].

REFERENCE

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REVIEW

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Package List Price ($)
$ 529