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Cytokeratin 8 antibody [RCK106]

Anti-Cytokeratin 8 antibody [RCK106] used in IHC (Paraffin sections) (IHC-P). GTX29219
Anti-Cytokeratin 8 antibody [RCK106] used in IHC (Frozen sections) (IHC-Fr). GTX29219
Anti-Cytokeratin 8 antibody [RCK106] used in IHC (Frozen sections) (IHC-Fr). GTX29219

Cat. No. GTX29219

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 RCK106

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-P, IHC-Fr, FACS, Dot

Reactivity

 Human
Package
100 μg ($399)
See all Cytokeratin 8 products

APPLICATION

Application Note

Recommended dilutions: Dot: 1/100 - 1/1000. FACS: 1/100 - 1/200. ICC: Use at an assay dependent dilution. IHC-Fr: 1/100 - 1/200. WB: 1/100 - 1/1000.

Calculated MW

54 kDa. ( Note )

Product Note

This antibody reacts exclusively with cytokeratin 18 which is present in glandular epithelial cells of the digestive, respiratory, and urogenital tracts, endocrine and exocrine cells and mesothelial cells, as well as adenocarcinomas originating from them.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Cytokeratins from the human bladder carcinoma cell line T24.

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

keratin 8 , CARD2 , CK-8 , CK8 , CYK8 , K2C8 , K8 , KO

Cellular Localization

Cytoplasm , nucleoplasm

Background

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Database

Research Area

DATA IMAGES

Anti-Cytokeratin 8 antibody [RCK106] used in IHC (Paraffin sections) (IHC-P). GTX29219

GTX29219 IHC-P Image

Immunohistochemistry on paraffin section of human colon

Anti-Cytokeratin 8 antibody [RCK106] used in IHC (Frozen sections) (IHC-Fr). GTX29219

GTX29219 IHC-Fr Image

Immunohistochemistry on frozen section of human small intestine

Anti-Cytokeratin 8 antibody [RCK106] used in IHC (Frozen sections) (IHC-Fr). GTX29219

GTX29219 IHC-Fr Image

Immunohistochemistry on frozen section of human kidney

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399