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DAP12 antibody

Anti-DAP12 antibody used in IHC (Paraffin sections) (IHC-P). GTX32551
Anti-DAP12 antibody used in IHC (Paraffin sections) (IHC-P). GTX32551

Cat No. GTX32551

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

IHC-P

Reactivity

Mouse, Rat
Package
100 μl ($329)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

12 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 0.02% sodium azide, 50% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-113 of human TYROBP (NP_003323.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

TYRO protein tyrosine kinase binding protein , DAP12 , KARAP , PLOSL , PLOSL1

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

Database

Research Area

DATA IMAGES

Anti-DAP12 antibody used in IHC (Paraffin sections) (IHC-P). GTX32551

GTX32551 IHC-P Image

IHC-P analysis of rat heart tissue using GTX32551 DAP12 antibody.
Dilution : 1:100

Anti-DAP12 antibody used in IHC (Paraffin sections) (IHC-P). GTX32551

GTX32551 IHC-P Image

IHC-P analysis of mouse lung tissue using GTX32551 DAP12 antibody.
Dilution : 1:100

REFERENCE

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REVIEW

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