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DC-SIGN antibody [120507]

Cat No. GTX13487

Host

Mouse

Clonality

Monoclonal

Clone Name

120507

Isotype

IgG2b

Application

WB, ICC/IF, IHC-P, FACS

Reactivity

Human
Package
100 μg ($379)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1 μg/ml
ICC/IF 8-25 μg/ml
IHC-P 8-25 μg/ml
FACS 2.5 μg/1 × 10⁶ cells
Not tested in other applications.

Calculated MW

46 kDa. ( Note )

Product Note

Recognizes human DC-SIGN on transfected cells and on monocyte derived dentritic cells. The antibody does not react with either parental mouse cells or irrelevant transfectants, such as human DC-SIGN2.

PROPERTIES

Form

Liquid

Buffer

PBS, 5% Trehalose

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

purified from NIH/3T3 cells transfected with recombinant human DC-SIGN.

Purification

Purified immunoglobulin

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CD209 molecule , CDSIGN , CLEC4L , DC-SIGN , DC-SIGN1

Background

Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV1, HIV2 and SIV bind to DCs via DCSIGN. ICAM3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DCSIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

Database

Research Area

REFERENCE

There are currently no references for DC-SIGN antibody [120507] (GTX13487). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for DC-SIGN antibody [120507] (GTX13487). Be the first to share your experience with this product.
SDS
PBS.pdf
Package List Price ($)
$ 379