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DC-SIGN antibody [5D7]

Anti-DC-SIGN antibody [5D7] used in Western Blot (WB). GTX84994
Anti-DC-SIGN antibody [5D7] used in IHC (Paraffin sections) (IHC-P). GTX84994

Cat No. GTX84994

Host

Mouse

Clonality

Monoclonal

Clone Name

5D7

Isotype

IgG1

Application

WB, IHC-P, ELISA

Reactivity

Human
Package
100 μg ($399)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1 - 2 μg/mL
IHC-P 5 - 10 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

46 kDa. ( Note )

Positive Control

Human Uterus Tissue Lysate(GTX15392) , Human Lymph node Tissue Lysate(GTX29055)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CD209 molecule , CDSIGN , CLEC4L , DC-SIGN , DC-SIGN1

Background

Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes (1), where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN (2). ICAM-3 is the natural ligand for DC-SIGN (3). A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently (4-8). DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR (8). The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

Database

Research Area

DATA IMAGES

Anti-DC-SIGN antibody [5D7] used in Western Blot (WB). GTX84994

GTX84994 WB Image

WB analysis of human placenta tissue lysate using GTX84994 DC-SIGN antibody [5D7].
Working concentration : (A) 1 and (B) 2 μg/ml

Anti-DC-SIGN antibody [5D7] used in IHC (Paraffin sections) (IHC-P). GTX84994

GTX84994 IHC-P Image

IHC-P analysis of lymph node tissue using GTX84994 DC-SIGN antibody [5D7].
Working concentration : 5 μg/ml

REFERENCE

There are currently no references for DC-SIGN antibody [5D7] (GTX84994). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for DC-SIGN antibody [5D7] (GTX84994). Be the first to share your experience with this product.
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399