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DC-SIGN antibody [8B6]

Anti-DC-SIGN antibody [8B6] used in IHC (Paraffin sections) (IHC-P). GTX84993
Anti-DC-SIGN antibody [8B6] used in Western Blot (WB). GTX84993

Cat. No. GTX84993

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 8B6

Isotype

 IgG1

Application

 WB, IHC-P, ELISA

Reactivity

 Human
Package
100 μg ($429)
See all DC-SIGN products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 - 2 mg/mL
IHC-P 5 - 10 mg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

46 kDa. ( Note )

Positive Control

Human Uterus Tissue Lysate(GTX15392) , Human Lymph node Tissue Lysate(GTX29055)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD209 molecule , CDSIGN , CLEC4L , DC-SIGN , DC-SIGN1

Background

Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes (1), where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN (2). ICAM-3 is the natural ligand for DC-SIGN (3). A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently (4-8). DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit (8). The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

Database

Research Area

DATA IMAGES

Anti-DC-SIGN antibody [8B6] used in IHC (Paraffin sections) (IHC-P). GTX84993

GTX84993 IHC-P Image

IHC-P analysis of lymph node tissue using GTX84993 DC-SIGN antibody [8B6].
Working concentration : 10 μg/ml

Anti-DC-SIGN antibody [8B6] used in Western Blot (WB). GTX84993

GTX84993 WB Image

WB analysis of human uterus tissue lysate using GTX84993 DC-SIGN antibody [8B6].
Working concentration : (A) 1 and (B) 2 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 429