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DC-SIGN antibody [C209/1781]

Anti-DC-SIGN antibody [C209/1781] used in IHC (Paraffin sections) (IHC-P). GTX34673
Anti-DC-SIGN antibody [C209/1781] used in IHC (Paraffin sections) (IHC-P). GTX34673
Anti-DC-SIGN antibody [C209/1781] used in IHC (Paraffin sections) (IHC-P). GTX34673

Cat No. GTX34673

Host

Mouse

Clonality

Monoclonal

Clone Name

C209/1781

Isotype

IgG2b

Application

ICC/IF, IHC-P

Reactivity

Human
Package
100 μg ($429)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF 1-2ug/ml
IHC-P 0.5-1ug/ml for 30 minutes at RT

Note :

IHC-P
Boiling tissue sections in 10mM Tris with 1mM EDTA Buffer, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes

Not tested in other applications.

Calculated MW

46 kDa. ( Note )

Specificity/Sensitivity

DC-SIGN is a transmembrane receptor that is expressed on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization, which allows the receptor to bind multivalent ligands with high avidity.

PROPERTIES

Form

Liquid

Buffer

10mM PBS with 0.05% BSA, 0.05% azide (Please contact us for PBS only format)

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml

Antigen Species

Human

Immunogen

Recombinant human CD209 protein fragment

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Cd209 Molecule , Cdsign , Clec4L , Dc-Sign , Dc-Sign1 , Cd209

Background

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant i

Database

Research Area

DATA IMAGES

Anti-DC-SIGN antibody [C209/1781] used in IHC (Paraffin sections) (IHC-P). GTX34673

GTX34673 IHC-P Image

Formalin-fixed, paraffin-embedded human Lung Carcinoma stained with CD209 Monoclonal Antibody (C209/1781).

Anti-DC-SIGN antibody [C209/1781] used in IHC (Paraffin sections) (IHC-P). GTX34673

GTX34673 IHC-P Image

Formalin-fixed, paraffin-embedded human Small Intestine stained with CD209 Monoclonal Antibody (C209/1781).

Anti-DC-SIGN antibody [C209/1781] used in IHC (Paraffin sections) (IHC-P). GTX34673

GTX34673 IHC-P Image

Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with CD209 Monoclonal Antibody (C209/1781).

REFERENCE

There are currently no references for DC-SIGN antibody [C209/1781] (GTX34673). Be the first to share your publications with this product.

REVIEW

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