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DC-SIGN antibody [C209/1781]

Anti-DC-SIGN antibody [C209/1781] used in IHC (Paraffin sections) (IHC-P). GTX34673
Anti-DC-SIGN antibody [C209/1781] used in IHC (Paraffin sections) (IHC-P). GTX34673
Anti-DC-SIGN antibody [C209/1781] used in Western Blot (WB). GTX34673
Anti-DC-SIGN antibody [C209/1781] used in IHC (Paraffin sections) (IHC-P). GTX34673

Cat No. GTX34673

Host

Mouse

Clonality

Monoclonal

Clone Name

C209/1781

Isotype

IgG2b

Application

WB, IHC-P

Reactivity

Human
Package
100 μg ($339)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1-2μg/ml
IHC-P 1-2μg/ml for 30 minutes at RT

Note :

IHC-P
Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10mM Tris buffer with 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes.

Not tested in other applications.

Calculated MW

46 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA, 0.05% sodium azide (Please contact us for PBS only format)

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human CD209 protein fragment (exact sequence is proprietary)

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CD209 , CD209 molecule , CDSIGN , CLEC4L , DCSIGN , DCSIGN1 , DC-SIGN , DC SIGN

Cellular Localization

Cell membrane,Secreted

Background

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]

Database

Research Area

DATA IMAGES

Anti-DC-SIGN antibody [C209/1781] used in IHC (Paraffin sections) (IHC-P). GTX34673

GTX34673 IHC-P Image

IHC-P analysis of human colon carcinoma tissue using GTX34673 DC-SIGN antibody [C209/1781].

Anti-DC-SIGN antibody [C209/1781] used in IHC (Paraffin sections) (IHC-P). GTX34673

GTX34673 IHC-P Image

IHC-P analysis of human lung carcinoma tissue using GTX34673 DC-SIGN antibody [C209/1781].

Anti-DC-SIGN antibody [C209/1781] used in Western Blot (WB). GTX34673

GTX34673 WB Image

WB analysis of human liver and spleen tissue lysates using GTX34673 DC-SIGN antibody [C209/1781].

Anti-DC-SIGN antibody [C209/1781] used in IHC (Paraffin sections) (IHC-P). GTX34673

GTX34673 IHC-P Image

IHC-P analysis of human small intestine tissue using GTX34673 DC-SIGN antibody [C209/1781].

REFERENCE

There are currently no references for DC-SIGN antibody [C209/1781] (GTX34673). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for DC-SIGN antibody [C209/1781] (GTX34673). Be the first to share your experience with this product.
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 339