GeneTex
  • Country / Location Selection

United States (US)

DC-SIGN antibody [MR-1] (Low endotoxin, azide free)

Anti-DC-SIGN antibody [MR-1] (Low endotoxin, azide free) used in Flow cytometry (FACS). GTX42261

Cat No. GTX42261

Host

Mouse

Clonality

Monoclonal

Clone Name

MR-1

Isotype

IgG1

Application

ICC/IF, FACS, Neutralizing/Inhibition

Reactivity

Human
Package
100 μg ($379)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF Assay dependent
FACS Assay dependent
Neutralizing/Inhibition Assay dependent

Note :

Neutralizing/Inhibition
Mouse anti Human CD209 antibody, clone MR-1 is reported to partially block the functional activity of DC-SIGN (Melero et al.).

Not tested in other applications.

Calculated MW

46 kDa. ( Note )

Product Note

This antibody recognizes human DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN).

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Immature myeloid monocyte-derived dendritic cells (MDDCs).

Purification

Protein A purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CD209 molecule , CDSIGN , CLEC4L , DC-SIGN , DC-SIGN1

Background

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]

Database

Research Area

DATA IMAGES

Anti-DC-SIGN antibody [MR-1] (Low endotoxin, azide free) used in Flow cytometry (FACS). GTX42261

GTX42261 FACS Image

FACS analysis of human DC-SIGN transfected K562 cells using GTX42261 DC-SIGN antibody [MR-1] (Low endotoxin, azide free).

REFERENCE

There are currently no references for DC-SIGN antibody [MR-1] (Low endotoxin, azide free) (GTX42261). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for DC-SIGN antibody [MR-1] (Low endotoxin, azide free) (GTX42261). Be the first to share your experience with this product.
SDS
PBS.pdf
Package List Price ($)
$ 379
Custom Conjugations